Article

Anticodon Engineered Transfer RNAs (ACE-tRNAs) are a Platform Technology for Suppressing Nonsense Mutations

2024-06-06

Abstract excerpt

<h4>SUMMARY</h4> Nonsense mutations arise from single nucleotide substitutions that result in premature termination codons (PTCs). PTCs result in little to no full-length protein production and loss of mRNA expression through the nonsense-mediated mRNA decay (NMD) pathway. We demonstrate that anticodon engineered (ACE-) tRNAs efficiently suppress the most prevalent cystic fibrosis (CF) causing PTCs, promoting sig...

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Literature Corpus work: 2409fe04-569a-5e6d-b42d-90341701f187
DOI: 10.1101/2024.06.06.597760

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