Article
An extended Shine-Dalgarno sequence in mRNA functionally bypasses a vital defect in initiator tRNA.
Proceedings of the National Academy of Sciences of the United States of America - 7 Oct 2014
Shetty Sunil, Nadimpalli HimaPriyanka, Shah Riyaz Ahmad, Arora Smriti, Das Gautam, Varshney Umesh
Abstract excerpt
Initiator tRNAs are special in their direct binding to the ribosomal P-site due to the hallmark occurrence of the three consecutive G-C base pairs (3GC pairs) in their anticodon stems. How the 3GC pairs function in this role, has remained unsolved. We show that mutations in either the mRNA or 16S rRNA leading to extended interaction between the Shine-Dalgarno (SD) and anti-SD sequences compensate for the vital...
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