Article
Relationship between the structure and function of Escherichia coli initiator tRNA.
Biochimie - 1 Jan 1993
Dyson M R, Mandal N, RajBhandary U L
Abstract excerpt
Through functional studies of mutant tRNAs, we have identified sequence and/or structural features important for specifying the many distinctive properties of E coli initiator tRNA. Many of the mutant tRNAs contain an anticodon sequence change from CAU-->CUA and are now substrates for E coli glutaminyl-tRNA synthetase (GlnRS). We describe here the effect of further mutating the discriminator base 73 and...
Topics
- Acyltransferases
- Amino Acyl-tRNA Synthetases
- Base Sequence
- Binding Sites
- Escherichia coli
- Hydroxymethyl and Formyl Transferases
- Immunoblotting
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Peptide Chain Initiation, Translational