Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ACE-tRNAs are a platform technology for suppressing nonsense mutations that cause cystic fibrosis

8 Jul 2025

Abstract excerpt

Nonsense mutations arise from single nucleotide substitutions that result in premature termination codons (PTCs). PTCs result in little to no full-length protein production and decreased mRNA stability due to the nonsense-mediated mRNA decay (NMD) pathway. We provide evidence that anticodon-edited (ACE-) tRNAs efficiently suppress the most prevalent cystic fibrosis (CF)-causing PTCs, promoting significant rescue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced biosensing and bioanalysis techniques
Share to Cystic Fibrosis Research Advances
Share to RNA and protein synthesis mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40650978
DOI: 10.1093/nar/gkaf675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ACE-tRNAs are a platform technology for suppressing nonsense mutations that cause cystic fibrosisPMID 40650978Read ↗

Anticodon Engineered Transfer RNAs (ACE-tRNAs) are a Platform Technology for Suppressing Nonsense MutationsSemantic proximity Read ↗

Efficient suppression of endogenous CFTR nonsense mutations using anticodon-engineered transfer RNAsSemantic proximity Read ↗

Efficient Suppression of Endogenous CFTR Nonsense Mutations Using Anticodon Engineered Transfer RNAsSemantic proximity Read ↗

Optimization of Anticodon Edited Transfer RNAs (ACE-tRNAs) Function in Translation for Suppression of Nonsense MutationsSemantic proximity Read ↗

Engineered transfer RNAs for suppression of premature termination codonsSemantic proximity Read ↗

Therapeutic promise of engineered nonsense suppressor tRNAs.Semantic proximity Read ↗

Engineered tRNA suppression of a CFTR nonsense mutationSemantic proximity Read ↗

Anticodon Edited Transfer RNAs (ACE-tRNAs) Encoded as Therapeutic Nonviral Minimal DNA VectorsSemantic proximity Read ↗

Identification of the amino acids inserted during suppression of CFTR nonsense mutations and determination of their functional consequences.Semantic proximity Read ↗

Transfer RNA and small molecule therapeutics for aminoacyl-tRNA synthetase diseases.Semantic proximity Read ↗

High-fidelity and differential nonsense suppression in live cells and a frontotemporal dementia allele with human transfer RNAs.Semantic proximity Read ↗

Readthrough-induced misincorporated amino acid ratios guide mutant-specific therapeutic approaches for two CFTR nonsense mutationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.