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Article

Initiator-elongator discrimination in vertebrate tRNAs for protein synthesis.

Molecular and cellular biology - 1 Mar 1998

Drabkin H J, Estrella M, Rajbhandary U L

Abstract excerpt

Initiator tRNAs are used exclusively for initiation of protein synthesis and not for the elongation step. We show, in vivo and in vitro, that the primary sequence feature that prevents the human initiator tRNA from acting in the elongation step is the nature of base pairs 50:64 and 51:63 in the TpsiC stem of the initiator tRNA. Various considerations suggest that this is due to sequence-dependent perturbation of...

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Identifiers

PMID: 9488462
DOI: 10.1128/MCB.18.3.1459
PMCID: PMC108860

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Source receipt: pubmed, retrieved 7 Sept 2026.

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