Article
Initiator-elongator discrimination in vertebrate tRNAs for protein synthesis.
Molecular and cellular biology - 1 Mar 1998
Drabkin H J, Estrella M, Rajbhandary U L
Abstract excerpt
Initiator tRNAs are used exclusively for initiation of protein synthesis and not for the elongation step. We show, in vivo and in vitro, that the primary sequence feature that prevents the human initiator tRNA from acting in the elongation step is the nature of base pairs 50:64 and 51:63 in the T...
Topics
- Acylation
- Animals
- Base Composition
- Base Sequence
- COS Cells
- Cell Extracts
- Cell Line
- Chlorocebus aethiops
- Conserved Sequence
- Eukaryotic Cells
- Genes, Reporter
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Peptide Chain Elongation, Translational
- Peptide Chain Initiation, Translational
- Protein Biosynthesis