Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An evolutionarily conserved element in initiator tRNAs prompts ultimate steps in ribosome maturation.

Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2016

Shetty Sunil, Varshney Umesh

Abstract excerpt

Ribosome biogenesis, a complex multistep process, results in correct folding of rRNAs, incorporation of >50 ribosomal proteins, and their maturation. Deficiencies in ribosome biogenesis may result in varied faults in translation of mRNAs causing cellular toxicities and ribosomopathies in higher organisms. How cells ensure quality control in ribosome biogenesis for the fidelity of its complex function remains...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticodon
Share to GC Rich Sequence
Share to Peptide Initiation Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Synthesis Inhibitors

Share to Response Elements

Share to Ribosomes

Share to RNA Processing, Post-Transcriptional

Share to RNA, Transfer

Source

Open in PubMed Open full text

Identifiers

PMID: 27698115
DOI: 10.1073/pnas.1609550113
PMCID: PMC5068261

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An evolutionarily conserved element in initiator tRNAs prompts ultimate steps in ribosome maturation.PMID 27698115Read ↗

An Alternative Role of RluD in the Fidelity of Translation Initiation in Escherichia coli.Semantic proximity Read ↗

Adaptor Molecules Epitranscriptome Reprograms Bacterial PathogenicitySemantic proximity Read ↗

Distinctive contributions of the ribosomal P-site elements m2G966, m5C967 and the C-terminal tail of the S9 protein in the fidelity of initiation of translation in Escherichia coli.Semantic proximity Read ↗

Two highly conserved features of bacterial initiator tRNAs license them to pass through distinct checkpoints in translation initiation.Semantic proximity Read ↗

Crucial contribution of the multiple copies of the initiator tRNA genes in the fidelity of tRNA(fMet) selection on the ribosomal P-site in Escherichia coli.Semantic proximity Read ↗

An extended Shine-Dalgarno sequence in mRNA functionally bypasses a vital defect in initiator tRNA.Semantic proximity Read ↗

Repurposing tRNA isodecoders for non-canonical functions via tRNA cleavageSemantic proximity Read ↗

Recycling of ribosomal complexes stalled at the step of elongation in Escherichia coli.Semantic proximity Read ↗

Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon.Semantic proximity Read ↗

Generation of pre-tRNAs from polycistronic operons is the essential function of RNase P in Escherichia coli.Semantic proximity Read ↗

Role of 16S ribosomal RNA methylations in translation initiation in Escherichia coli.Semantic proximity Read ↗

Charging the code — tRNA modification complexesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.