Article
Identification of protein-damaging mutations in 10 swine taste receptors and 191 appetite-reward genes.
BMC genomics - 26 Aug 2016
Clop Alex, Sharaf Abdoallah, Castelló Anna, Ramos-Onsins Sebastián, Cirera Susanna, Mercadé Anna, Derdak Sophia, Beltran Sergi, Huisman Abe, Fredholm Merete, van As Pieter, Sánchez Armand
Abstract excerpt
BACKGROUND: Taste receptors (TASRs) are essential for the body's recognition of chemical compounds. In the tongue, TASRs sense the sweet and umami and the toxin-related bitter taste thus promoting a particular eating behaviour. Moreover, their relevance in other organs is now becoming evident. In the intestine, they regulate nutrient absorption and gut motility. Upon ligand binding, TASRs activate the...
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