Article
Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer.
BMC gastroenterology - 15 Sept 2017
Barontini Jonathan, Antinucci Marco, Tofanelli Sergio, Cammalleri Maurizio, Dal Monte Massimo, Gemignani Federica, Vodicka Pavel, Marangoni Roberto, Vodickova Ludmila, Kupcinskas Juozas, Vymetalkova Veronika, Forsti Asta, Canzian Federico, Stein Angelika, Moreno Victor, Mastrodonato Nicola, Tavano Francesca, Panza Anna, Barale Roberto, Landi Stefano, Campa Daniele
Abstract excerpt
BACKGROUND: Genetics plays an important role in the susceptibility to sporadic colorectal cancer (CRC). In the last 10 years genome-wide association studies (GWAS) have identified over 40 independent low penetrance polymorphic variants. However, these loci only explain around 1‑4% of CRC heritability, highlighting the dire need of identifying novel risk loci. In this study, we focused our attention on the genetic...
Topics
- Aged
- Case-Control Studies
- Colonic Neoplasms
- Czech Republic
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Italy