Cooperative regulation of neurotransmitter release by Rab3a and synapsin II.

doi:10.1016/j.mcn.2010.03.007

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Article

Cooperative regulation of neurotransmitter release by Rab3a and synapsin II.

Molecular and cellular neurosciences - 1 Jun 2010

Coleman William L, Bykhovskaia Maria

Abstract excerpt

To understand how the presynaptic proteins synapsin and Rab3a may interact in the regulation of the synaptic vesicle cycle and the release process, we derived a double knockout (DKO) mouse lacking both synapsin II and Rab3a. We found that Rab3a deletion rescued epileptic-like seizures typical for synapsin II gene deleted animals (Syn II(-)). Furthermore, action potential evoked release was drastically reduced in...

Topics

Animals
Brain
Calcium Signaling
Epilepsy
Excitatory Postsynaptic Potentials
Long-Term Synaptic Depression
Mice
Mice, Knockout
Microscopy, Electron, Transmission
Neurotransmitter Agents
Phenotype
Presynaptic Terminals
Synapsins
Synaptic Transmission
Synaptic Vesicles
rab3A GTP-Binding Protein

Source

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Identifiers

PMID: 20338242
DOI: 10.1016/j.mcn.2010.03.007
PMCID: PMC4522281

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