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Article

The impact of mineralocorticoid receptor ISO/VAL genotype (rs5522) and stress on reward learning.

Genes, brain, and behavior - 1 Aug 2010

Bogdan R, Perlis R H, Fagerness J, Pizzagalli D A

Abstract excerpt

Research suggests that stress disrupts reinforcement learning and induces anhedonia. The mineralocorticoid receptor (MR) determines the sensitivity of the stress response, and the missense iso/val polymorphism (Ile180Val, rs5522) of the MR gene (NR3C2) has been associated with enhanced physiologi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20528958
DOI: 10.1111/j.1601-183X.2010.00600.x
PMCID: PMC2921022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20528958-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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