Perception of a naturalistic stressor interacts with 5-HTTLPR/rs25531 genotype and gender to impact reward responsiveness.

doi:10.1159/000329105

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Article

Perception of a naturalistic stressor interacts with 5-HTTLPR/rs25531 genotype and gender to impact reward responsiveness.

Neuropsychobiology - 1 Jan 2012

Nikolova Yuliya, Bogdan Ryan, Pizzagalli Diego A

Abstract excerpt

BACKGROUND: Stressful life experiences frequently precede the onset of major depression; however, the mechanisms that underlie this link are poorly understood. Importantly, some individuals are more susceptible to the depressogenic effects of stress than others. Carriers of the S or LG allele of the 5-HTTLPR/rs25531 polymorphisms (S' participants) have been found to be more prone to developing depression under...

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PMID: 22094432
DOI: 10.1159/000329105
PMCID: PMC3238029

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