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HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors

30 Jan 2018

Abstract excerpt

BACKGROUND: Approximately one in five breast cancers are driven by amplification and overexpression of the human epidermal growth factor receptor 2 (HER2) receptor kinase, and HER2-enriched (HER2E) is one of four major transcriptional subtypes of breast cancer. We set out to understand the genomics of HER2 amplification independent of subtype, and the underlying drivers and biology of HER2E tumors. METHODS: We...

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PMID: 29382369
DOI: 10.1186/s13058-018-0933-y

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