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Article

Role of Genomic Alterations in HER2 Positive Breast Carcinoma: Focus on Susceptibility and Trastuzumab-therapy.

Current cancer drug targets - 1 Jan 2017

Singla Heena, Kalra Sourav, Kheterpal Preeti, Kumar Vinod, Munshi Anjana

Abstract excerpt

BACKGROUND: Breast cancer is the most frequently diagnosed life-threatening malignancy among women, across the globe. HER2 positive is a distinct breast cancer subtype, on account of its unique biology and physiological behavior. RESULTS: Amplification of HER2 oncogene/polysomy 17 leads to HER2 overexpression that is a significant causal implication in HER2 positive breast cancer. HER2 gene variants, as well as...

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Identifiers

PMID: 27993117
DOI: 10.2174/1568009616666161216094026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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