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Article

Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos.

Nature medicine - 1 Jul 2010

Beronja Slobodan, Livshits Geulah, Williams Scott, Fuchs Elaine

Abstract excerpt

Using ultrasound-guided in utero infections of fluorescently traceable lentiviruses carrying RNAi or Cre recombinase into mouse embryos, we have demonstrated noninvasive, highly efficient selective transduction of surface epithelium, in which progenitors stably incorporate and propagate the desired genetic alterations. We achieved epidermal-specific infection using small generic promoters of existing lentiviral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20526348
DOI: 10.1038/nm.2167
PMCID: PMC2911018

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