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Article

RNA-seq Characterization of Melanoma Phenotype Switch in 3D Collagen after p38 MAPK Inhibitor Treatment.

Biomolecules - 17 Mar 2021

Čermák Vladimír, Škarková Aneta, Merta Ladislav, Kolomazníková Veronika, Palušová Veronika, Uldrijan Stjepan, Rösel Daniel, Brábek Jan

Abstract excerpt

Melanoma phenotype plasticity underlies tumour dissemination and resistance to therapy, yet its regulation is incompletely understood. In vivo switching between a more differentiated, proliferative phenotype and a dedifferentiated, invasive phenotype is directed by the tumour microenvironment. We found that treatment of partially dedifferentiated, invasive A375M2 cells with two structurally unrelated p38 MAPK...

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Identifiers

PMID: 33802847
DOI: 10.3390/biom11030449
PMCID: PMC8002814

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