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Article

Hypoxia contributes to melanoma heterogeneity by triggering HIF1α-dependent phenotype switching.

The Journal of investigative dermatology - 1 Oct 2013

Widmer Daniel S, Hoek Keith S, Cheng Phil F, Eichhoff Ossia M, Biedermann Thomas, Raaijmakers Marieke I G, Hemmi Silvio, Dummer Reinhard, Levesque Mitchell P

Abstract excerpt

We have previously reported a model for melanoma progression in which oscillation between melanoma cell phenotypes characterized by invasion or proliferation is fundamental to tumor heterogeneity and disease progression. In this study we examine the possible role of hypoxia as one of the microenvironmental influences driving metastatic progression by promoting a switch from a proliferative to an invasive...

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Source

Identifiers

PMID: 23474946
DOI: 10.1038/jid.2013.115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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