Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

gsk disruption leads to guanosine accumulation in Escherichia coli.

Bioscience, biotechnology, and biochemistry - 1 May 2001

Matsui H, Shimaoka M, Takenaka Y, Kawasaki H, Kurahashi O

Abstract excerpt

We tried some improvement of inosine production using an inosine-producing mutant of Escherichia coli which is deficient in purF (phosphoribosylpyrophosphate (PRPP) amidotransferase gene), purA (succinyl-adenosine 5'-monophosphate (AMP) synthetase gene), deoD (purine nucleoside phosphorylase gene), purR (purine repressor gene) and add (adenosine deaminase gene), and harboring the desensitized PRPP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography, High Pressure Liquid
Share to Escherichia coli
Share to Genes, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Guanosine

Share to Mutation

Share to Phosphotransferases (Alcohol Group Acceptor)

Share to Plasmids

Source

Identifiers

PMID: 11440147
DOI: 10.1271/bbb.65.1230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

gsk disruption leads to guanosine accumulation in Escherichia coli.PMID 11440147Read ↗

Investigation of various genotype characteristics for inosine accumulation in Escherichia coli W3110.Semantic proximity Read ↗

Effect of amplification of desensitized purF and prs on inosine accumulation in Escherichia coli.Semantic proximity Read ↗

Accumulation of gene-targeted Bacillus subtilis mutations that enhance fermentative inosine production.Semantic proximity Read ↗

Nucleotide mutations in purA gene and pur operon promoter discovered in guanosine- and inosine-producing Bacillus subtilis strains.Semantic proximity Read ↗

Complete deficiency of 5'-nucleotidase activity in Escherichia coli leads to loss of growth on purine nucleotides but not of their excretion.Semantic proximity Read ↗

Effects of edd and pgi disruptions on inosine accumulation in Escherichia coli.Semantic proximity Read ↗

Deregulation of purine pathway in Bacillus subtilis and its use in riboflavin biosynthesis.Semantic proximity Read ↗

Inhibition of cellular growth by increased guanine nucleotide pools. Characterization of an Escherichia coli mutant with a guanosine kinase that is insensitive to feedback inhibition by GTP.Semantic proximity Read ↗

In vivo effect of mutations at the PRPP binding site of the Bacillus subtilis purine repressor.Semantic proximity Read ↗

The CBS subdomain of inosine 5'-monophosphate dehydrogenase regulates purine nucleotide turnover.Semantic proximity Read ↗

[Adenine effect on the biosynthesis of 5'-inosinic acid by the mutant Brevibacterium ammoniagenes 225-5].Semantic proximity Read ↗

De novo engineering and metabolic flux analysis of inosine biosynthesis in Bacillus subtilis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.