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Article

A two-nucleotide deletion renders the mannose-binding lectin 2 (MBL2) gene nonfunctional in Danish Landrace and Duroc pigs.

Immunogenetics - 1 Mar 2014

Bergman I M, Edman K, van As P, Huisman A, Juul-Madsen Helle Risdahl

Abstract excerpt

The mannose-binding lectins (MBLs) are central components of innate immunity, facilitating phagocytosis and inducing the lectin activation pathway of the complement system. Previously, it has been found that certain single-nucleotide polymorphisms (SNPs) in porcine MBL1 and MBL2 (pMBL1, pMBL2) affect mRNA expression, serum concentration, and susceptibility to disease, but the combinatory effect of pMBL1 and pMBL2...

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PMID: 24477343
DOI: 10.1007/s00251-014-0758-5

Genes

MBL2

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