Article
Variation within DNA repair pathway genes and risk of multiple sclerosis.
American journal of epidemiology - 15 Jul 2010
Briggs Farren B S, Goldstein Benjamin A, McCauley Jacob L, Zuvich Rebecca L, De Jager Philip L, Rioux John D, Ivinson Adrian J, Compston Alastair, Hafler David A, Hauser Stephen L, Oksenberg Jorge R, Sawcer Stephen J, Pericak-Vance Margaret A, Haines Jonathan L, Barcellos Lisa F
Abstract excerpt
Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system with a prominent genetic component. The primary genetic risk factor is the human leukocyte antigen (HLA)-DRB1*1501 allele; however, much of the remaining genetic contribution to MS has not been elucidated. The authors investigated the relation between variation in DNA repair pathway genes and risk of MS. Single-locus association...
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