Article
Combinations of susceptibility genes are associated with higher risk for multiple sclerosis and imply disease course specificity.
PloS one - 1 Jan 2015
Akkad Denis A, Olischewsky Alexandra, Reiner Franziska, Hellwig Kerstin, Esser Sarika, Epplen Jörg T, Curk Tomaz, Gold Ralf, Haghikia Aiden
Abstract excerpt
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that predominantly affects young adults. The genetic contributions to this multifactorial disease were underscored by a genome wide association study (GWAS) conducted by the International Multiple Sclerosis Genetic Consortium in a multinational cohort prompting the discovery of 57 non-MHC MS-associated common genetic variants....
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