Article
Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals.
Human molecular genetics - 1 Nov 2010
Briggs Farren B S, Bartlett Selena E, Goldstein Benjamin A, Wang Joanne, McCauley Jacob L, Zuvich Rebecca L, De Jager Philip L, Rioux John D, Ivinson Adrian J, Compston Alastair, Hafler David A, Hauser Stephen L, Oksenberg Jorge R, Sawcer Stephen J, Pericak-Vance Margaret A, Haines Jonathan L, Barcellos Lisa F
Abstract excerpt
The primary genetic risk factor in multiple sclerosis (MS) is the HLA-DRB1*1501 allele; however, much of the remaining genetic contribution to MS has yet to be elucidated. Several lines of evidence support a role for neuroendocrine system involvement in autoimmunity which may, in part, be genetic...
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