Article
Discovery of a novel imprinted gene by transcriptional analysis of parthenogenetic embryonic stem cells.
Human reproduction (Oxford, England) - 1 Aug 2010
Sritanaudomchai Hathaitip, Ma Hong, Clepper Lisa, Gokhale Sumita, Bogan Randy, Hennebold Jon, Wolf Don, Mitalipov Shoukhrat
Abstract excerpt
BACKGROUND: Parthenogenetic embryonic stem cells (PESCs) may have future utilities in cell replacement therapies since they are closely related to the female from which the activated oocyte was obtained. Furthermore, the avoidance of parthenogenetic development in mammals provides the most compelling rationale for the evolution of genomic imprinting, and the biological process of parthenogenesis raises complex...
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