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Reprogramming mechanism dissection and trophoblast replacement application in monkey somatic cell nuclear transfer

16 Jan 2024

Abstract excerpt

Somatic cell nuclear transfer (SCNT) successfully clones cynomolgus monkeys, but the efficiency remains low due to a limited understanding of the reprogramming mechanism. Notably, no rhesus monkey has been cloned through SCNT so far. Our study conducts a comparative analysis of multi-omics datasets, comparing embryos resulting from intracytoplasmic sperm injection (ICSI) with those from SCNT. Our findings reveal...

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PMID: 38228612
DOI: 10.1038/s41467-023-43985-7

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