Article
Functional genomics and cancer drug target discovery.
Current opinion in molecular therapeutics - 1 Jun 2010
Moody Susan E, Boehm Jesse S, Barbie David A, Hahn William C
Abstract excerpt
The recent development of technologies for whole-genome sequencing, copy number analysis and expression profiling enables the generation of comprehensive descriptions of cancer genomes. However, although the structural analysis and expression profiling of tumors and cancer cell lines can allow the identification of candidate molecules that are altered in the malignant state, functional analyses are necessary to...
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