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Article

Malignancy of Cancers and Synthetic Lethal Interactions Associated With Mutations of Cancer Driver Genes.

Medicine - 1 Feb 2016

Wang Xiaosheng, Zhang Yue, Han Ze-Guang, He Kun-Yan

Abstract excerpt

The mutation status of cancer driver genes may correlate with different degrees of malignancy of cancers. The doubling time and multidrug resistance are 2 phenotypes that reflect the degree of malignancy of cancer cells. Because most of cancer driver genes are hard to target, identification of their synthetic lethal partners might be a viable approach to treatment of the cancers with the relevant mutations.The...

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Source

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Identifiers

PMID: 26937901
DOI: 10.1097/MD.0000000000002697
PMCID: PMC4778998

Genes

APC
KRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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