Article
High throughput functional genomics: identification of novel genes with tumor suppressor phenotypes.
International journal of cancer - 20 Jan 2005
Koenig-Hoffmann Kerstin, Bonin-Debs Angelika L, Boche Irene, Gawin Beate, Gnirke Andrea, Hergersberg Christoph, Madeo Frank, Kazinski Michael, Klein Matthias, Korherr Christian, Link Dieter, Röhrig Sascha, Schäfer Rolf, Brinkmann Ulrich
Abstract excerpt
We have used a combination of high throughput functional genomics, computerized database mining and expression analyses to discover novel human tumor suppressor genes (TSGs). A genome-wide high throughput cDNA phenotype screen was established to identify genes that induce apoptosis or reduce cell viability. TSGs are expressed in normal tissue and frequently act by reduction of growth of transformed cells or...
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