Article
Interplay of the Ca2+-binding protein DREAM with presenilin in neuronal Ca2+ signaling.
The Journal of biological chemistry - 10 Oct 2008
Fedrizzi Laura, Lim Dmitry, Carafoli Ernesto, Brini Marisa
Abstract excerpt
The Ca(2+)-binding protein DREAM regulates gene transcription and Kv potassium channels in neurons but has also been claimed to interact with presenilins, which are involved in the generation of beta-amyloid and in the regulation of the Ca(2+) content in the endoplasmic reticulum. The role of DREAM in Ca(2+) homeostasis was thus explored in SH-SY5Y cells stably or transiently overexpressing DREAM or a...
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