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Article

Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction.

Journal of medicinal chemistry - 23 Oct 2008

Bach Anders, Chi Celestine N, Olsen Thomas B, Pedersen Søren W, Røder Martin U, Pang Gar F, Clausen Rasmus P, Jemth Per, Strømgaard Kristian

Abstract excerpt

The protein-protein interaction between the NMDA receptor and its intracellular scaffolding protein, PSD-95, is a potential target for treatment of ischemic brain diseases. An undecapeptide corresponding to the C-terminal of the NMDA was used as a template for finding lead candidates for the inhibition of the PSD-95/NMDA receptor interaction. Initially, truncation and alanine scan studies were carried out, which...

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Identifiers

PMID: 18811137
DOI: 10.1021/jm800836w

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PSD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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