Ciliary neurotrophic factor cell-based delivery prevents synaptic impairment and improves memory in mouse models of Alzheimer's disease.

doi:10.1523/JNEUROSCI.4182-09.2010

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Article

Ciliary neurotrophic factor cell-based delivery prevents synaptic impairment and improves memory in mouse models of Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Jun 2010

Garcia Pierre, Youssef Ihsen, Utvik Jo K, Florent-Béchard Sabrina, Barthélémy Vanassa, Malaplate-Armand Catherine, Kriem Badreddine, Stenger Christophe, Koziel Violette, Olivier Jean-Luc, Escanye Marie-Christine, Hanse Marine, Allouche Ahmad, Desbène Cédric, Yen Frances T, Bjerkvig Rolf, Oster Thierry, Niclou Simone P, Pillot Thierry

Abstract excerpt

The development of novel therapeutic strategies for Alzheimer's disease (AD) represents one of the biggest unmet medical needs today. Application of neurotrophic factors able to modulate neuronal survival and synaptic connectivity is a promising therapeutic approach for AD. We aimed to determine whether the loco-regional delivery of ciliary neurotrophic factor (CNTF) could prevent amyloid-beta (Abeta)...

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PMID: 20519526
DOI: 10.1523/JNEUROSCI.4182-09.2010
PMCID: PMC6632372

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CNTF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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