Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease.

doi:10.1002/sctm.19-0327

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease.

Stem cells translational medicine - 1 Sept 2020

Losurdo Morris, Pedrazzoli Matteo, D'Agostino Claudia, Elia Chiara A, Massenzio Francesca, Lonati Elena, Mauri Mario, Rizzi Laura, Molteni Laura, Bresciani Elena, Dander Erica, D'Amico Giovanna, Bulbarelli Alessandra, Torsello Antonio, Matteoli Michela, Buffelli Mario, Coco Silvia

Abstract excerpt

The critical role of neuroinflammation in favoring and accelerating the pathogenic process in Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a potential therapeutic strategy to slow down the disease progression. In this scenario, mesenchymal stem cells (MSCs) have risen considerable interest thanks to their immunomodulatory properties, which have been largely ascribed to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Intranasal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, Differentiation, Myelomonocytic

Share to Dendritic Spines

Share to Extracellular Vesicles

Share to Immunomodulation

Share to Mesenchymal Stem Cells

Share to Microglia

Share to Neuroprotection

Source

Open in PubMed Open full text

Identifiers

PMID: 32496649
DOI: 10.1002/sctm.19-0327
PMCID: PMC7445021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease.PMID 32496649Read ↗

Intranasally Administered EVs from hiPSC-derived NSCs Alter the Transcriptomic Profile of Activated Microglia and Conserve Brain Function in an Alzheimer’s ModelSemantic proximity Read ↗

Intranasal Delivery of 3D-Bioprinted Mesenchymal Stem Cell-Derived Extracellular Vesicles Targeting Aβ Deposition and Neuroinflammation for Alzheimer’s Disease TherapySemantic proximity Read ↗

Intranasal delivery of engineered extracellular vesicles loaded with miR-206-3p antagomir ameliorates Alzheimer's disease phenotypes.Semantic proximity Read ↗

Mesenchymal Stem Cell-Derived Exosomes as a Neuroregeneration Treatment for Alzheimer's DiseaseSemantic proximity Read ↗

Mesenchymal Stem Cell-based Therapies Applied in Neurological DiseasesSemantic proximity Read ↗

Using Extracellular Vesicles Released by GDNF-transfected Macrophages for Therapy of Parkinson’s DiseaseSemantic proximity Read ↗

Viral vectors in neurodegenerative diseases: immune responses and therapeutic applicationsSemantic proximity Read ↗

Development of a High-throughput Morphological Assay for Evaluating Mesenchymal Stromal Cell-derived Extracellular Vesicle Modulation of Brain Pericyte Secretory Phenotype.Semantic proximity Read ↗

Cerebral microvascular endothelial cell-derived extracellular vesicles regulate blood−brain barrier functionSemantic proximity Read ↗

Development of a High-throughput Morphological Assay for Evaluating Mesenchymal Stromal Cell-derived Extracellular Vesicle Modulation of Brain Pericyte Secretory PhenotypeSemantic proximity Read ↗

Unveiling the role of miRNAs from MSC-EVs in neuroinflammation and behavioral impairments induced by chronic alcohol consumptionSemantic proximity Read ↗

Bone marrow-derived mesenchymal stem cells contribute to the reduction of amyloid-β deposits and the improvement of synaptic transmission in a mouse model of pre-dementia Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.