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Article

Lenti-GDNF gene therapy protects against Alzheimer's disease-like neuropathology in 3xTg-AD mice and MC65 cells.

CNS neuroscience & therapeutics - 1 Nov 2014

Revilla Susana, Ursulet Suzanna, Álvarez-López María Jesús, Castro-Freire Marco, Perpiñá Unai, García-Mesa Yoelvis, Bortolozzi Analía, Giménez-Llort Lydia, Kaliman Perla, Cristòfol Rosa, Sarkis Chamsy, Sanfeliu Coral

Abstract excerpt

AIMS: Glial cell-derived neurotrophic factor (GDNF) is emerging as a potent neurotrophic factor with therapeutic potential against a range of neurodegenerative conditions including Alzheimer's disease (AD). We assayed the effects of GDNF treatment in AD experimental models through gene-therapy procedures. METHODS: Recombinant lentiviral vectors were used to overexpress GDNF gene in hippocampal astrocytes of...

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Identifiers

PMID: 25119316
DOI: 10.1111/cns.12312
PMCID: PMC6493188

Genes

GDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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