Article
Association of putative functional variants in the PLAU gene and the PLAUR gene with myocardial infarction.
Clinical science (London, England : 1979) - 9 Jul 2010
Xu Jing, Li Wenlong, Bao Xunna, Ding Hu, Chen Jingzhou, Zhang Weili, Sun Kai, Wang Jizheng, Wang Xiaojian, Wang Hu, Yu Hui, Song Weihua, Ma Weiwei, Zhang Lin, Wang Changxin, Wang Daowen, Hui Rutai
Abstract excerpt
uPA (urokinase-plasminogen activator) and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction). We hypothesized that putative functional genetic variation in the two genes encoding uPA and uPAR (PLAU and...
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