Article
The exon 1-8C/G SNP in the PSMA6 gene contributes only a small amount to the burden of myocardial infarction in 6946 cases and 2720 controls from a United Kingdom population.
European journal of human genetics : EJHG - 1 Apr 2008
Bennett Derrick A, Xu Peng, Clarke Robert, Zondervan Krina, Parish Sarah, Palmer Alison, Cardon Lon, Peto Richard, Lathrop Mark, Collins Rory
Abstract excerpt
The proteasome system is a proteolytic pathway that regulates the expression of genes involved in inflammation. Polymorphisms in the gene encoding subunit alpha type 6 (PSMA6)--in particular the rs1048990 exon 1-8C/G SNP--have been implicated with susceptibility to myocardial infarction (MI) in a Japanese study. We examined whether several polymorphisms in the PSMA6 gene were related to MI risk in 6946 nonfatal...
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