A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease.

doi:10.1093/hmg/ddl167

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Article

A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease.

Human molecular genetics - 15 Aug 2006

Riemenschneider Matthias, Konta Lidija, Friedrich Patricia, Schwarz Sandra, Taddei Kevin, Neff Frauke, Padovani Alessandro, Kölsch Heike, Laws Simon M, Klopp Norman, Bickeböller Heike, Wagenpfeil Stefan, Mueller Jakob C, Rosenberger Albert, Diehl-Schmid Janine, Archetti Silvana, Lautenschlager Nicola, Borroni Barbara, Müller Ulrich, Illig Thomas, Heun Reinhard, Egensperger Rupert, Schlegel Jürgen, Förstl Hans, Martins Ralph N, Kurz Alexander

Abstract excerpt

A number of susceptibility loci for Alzheimer's disease (AD) have been identified including a region on Chromosome 10q21-q22. Within this region the plasminogen activator urokinase gene (PLAU) was considered as a reasonable candidate from its functional implication in plasmin generation, a serine protease capable of degrading beta-Amyloid (Abeta) protein. We screened 56 single nucleotide polymorphisms (SNPs)...

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PMID: 16825285
DOI: 10.1093/hmg/ddl167

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PLAU

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A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease.PMID 16825285Read ↗

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Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene.Semantic proximity Read ↗

Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2.Semantic proximity Read ↗

Association of tagSNPs in the urokinase-plasminogen activator (PLAU) gene with Alzheimer's disease and associated quantitative traits.Semantic proximity Read ↗

Gene Association Study of the Urokinase Plasminogen Activator and Its Receptor Gene in Alzheimer's Disease.Semantic proximity Read ↗

The urokinase-type plasminogen activator polymorphism PLAU_1 is a risk factor for APOE-epsilon4 non-carriers in the Italian Alzheimer's disease population and does not affect the plasma Abeta(1-42) level.Semantic proximity Read ↗

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