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Article

MAD1L1 Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer.

Scientific reports - 17 Jul 2015

Zhong Rong, Chen Xiaohua, Chen Xueqin, Zhu Beibei, Lou Jiao, Li Jiaoyuan, Shen Na, Yang Yang, Gong Yajie, Zhu Ying, Yuan Jing, Xia Xiaoping, Miao Xiaoping

Abstract excerpt

The spindle assembly checkpoint (SAC) has been established as an important mechanism of driving aneuploidy, which occurs at a high frequency in the colorectal tumorigenesis. Two important components of SAC are MAD1L1 and MAD2L1, which function together in an interactive manner to initiate the checkpoint signal. We hypothesize that genetic variants in the binding domains of MAD1L1 and MAD2L1 may modulate protein...

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Identifiers

PMID: 26183163
DOI: 10.1038/srep12202
PMCID: PMC4505328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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