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Article

Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers.

Oncogene - 25 Nov 1999

Nomoto S, Haruki N, Takahashi T, Masuda A, Koshikawa T, Takahashi T, Fujii Y, Osada H, Takahashi T

Abstract excerpt

We previously reported the presence of mitotic check-point impairment in about 40% of lung cancer cell lines. To gain an insight into the molecular basis of this impairment, we examined 49 lung cancer specimens for alterations in the hMAD1 mitotic checkpoint gene and identified a somatic, non-conservative missense mutation, which substitutes alanine (GCG) for threonine (ACG) at codon 299, together with a number...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10597320
DOI: 10.1038/sj.onc.1203141

Genes

GCG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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