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Article

The role of interchain heterodisulfide formation in activation of the human common beta and mouse betaIL-3 receptors.

The Journal of biological chemistry - 6 Aug 2010

Mirza Shamaruh, Chen Jinglong, Murphy James M, Young Ian G

Abstract excerpt

The cytokines, interleukin-3 (IL-3), interleukin-5 (IL-5), and granulocyte-macrophage colony-stimulating factor (GM-CSF), exhibit overlapping activities in the regulation of hematopoietic cells. In humans, the common beta (betac) receptor is shared by the three cytokines and functions together with cytokine-specific alpha subunits in signaling. A widely accepted hypothesis is that receptor activation requires...

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Identifiers

PMID: 20516062
DOI: 10.1074/jbc.M109.097881
PMCID: PMC2915712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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