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Article

Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains.

The Journal of biological chemistry - 17 Jun 2005

Zabeau Lennart, Defeau Delphine, Iserentant Hannes, Vandekerckhove Joël, Peelman Frank, Tavernier Jan

Abstract excerpt

The leptin receptor (LR) complex is composed of a single subunit belonging to the class I cytokine receptor family and exists as a preformed complex. The extracellular portion contains two cytokine receptor homology (CRH) domains, separated by an Ig-like domain and followed by two membrane-proximal fibronectin type III (FNIII) domains. The mechanisms underlying ligand-induced receptor activation are still poorly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15840566
DOI: 10.1074/jbc.M413308200

Genes

CRH
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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