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Article

Elder siblings enhance the effect of filaggrin mutations on childhood eczema: results from the 2 birth cohort studies LISAplus and GINIplus.

The Journal of allergy and clinical immunology - 1 Jun 2010

Cramer Claudia, Link Elke, Horster Maike, Koletzko Sibylle, Bauer Carl-P, Berdel Dietrich, von Berg Andrea, Lehmann Irina, Herbarth Olf, Borte Michael, Schaaf Beate, Behrendt Heidrun, Chen Chih-Mei, Sausenthaler Stefanie, Illig Thomas, Wichmann H-Erich, Heinrich Joachim, Krämer Ursula

Abstract excerpt

BACKGROUND: Several studies showed a protective effect of elder siblings on eczema development, which is in line with the hygiene hypothesis. However, findings are not consistent, and there might exist different causal pathways for the development of eczema. Especially barrier disturbances as found in children with mutations in the filaggrin gene (FLG) seem to play an important role. OBJECTIVES: To investigate...

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Identifiers

PMID: 20513523
DOI: 10.1016/j.jaci.2010.03.036

Genes

FLG

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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