Article
Filaggrin mutations in relation to skin barrier and atopic dermatitis in early infancy.
The British journal of dermatology - 1 Mar 2022
Hoyer A, Rehbinder E M, Färdig M, Asad S, Lødrup Carlsen K C, Endre K M A, Granum B, Haugen G, Hedlin G, Monceyron Jonassen C, Katayama S, Konradsen J R, Landrø L, LeBlanc M, Olsson Mägi C A, Rudi K, Skjerven H O, Staff A C, Vettukattil R, Bradley M, Nordlund B, Söderhäll C
Abstract excerpt
BACKGROUND: Loss-of-function mutations in the skin barrier gene filaggrin (FLG) increase the risk of atopic dermatitis (AD), but their role in skin barrier function, dry skin and eczema in infancy is unclear. OBJECTIVES: To determine the role of FLG mutations in impaired skin barrier function, dry skin, eczema and AD at 3 months of age and throughout infancy. METHODS: FLG mutations were analysed in 1836 infants...
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