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Article

Mutations affecting export and activity of cytolysin A from Escherichia coli.

Journal of bacteriology - 1 Aug 2010

Ludwig Albrecht, Völkerink Guido, von Rhein Christine, Bauer Susanne, Maier Elke, Bergmann Birgit, Goebel Werner, Benz Roland

Abstract excerpt

Cytolysin A (known as ClyA, HlyE, and SheA) is a cytolytic pore-forming protein toxin found in several Escherichia coli and Salmonella enterica strains. The structure of its water-soluble monomeric form and that of dodecameric ClyA pores is known, but the mechanisms of ClyA export from bacterial cells and of pore assembly are only partially understood. Here we used site-directed mutagenesis to study the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 20511497
DOI: 10.1128/JB.01283-09
PMCID: PMC2916382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations affecting export and activity of cytolysin A from Escherichia coli.PMID 20511497Read ↗

The deletion of several amino acid stretches of Escherichia coli alpha-hemolysin (HlyA) suggests that the channel-forming domain contains beta-strands.Semantic proximity Read ↗

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