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Article

Characterization of a pore-forming cytotoxin expressed by Salmonella enterica serovars typhi and paratyphi A.

Infection and immunity - 1 Oct 2002

Oscarsson Jan, Westermark Marie, Löfdahl Sven, Olsen Björn, Palmgren Helena, Mizunoe Yoshimitsu, Wai Sun Nyunt, Uhlin Bernt Eric

Abstract excerpt

Cytolysin A (ClyA) is a pore-forming cytotoxic protein encoded by the clyA gene that has been characterized so far only in Escherichia coli. Using DNA sequence analysis and PCR, we established that clyA is conserved in the human-specific typhoid Salmonella enterica serovars Typhi and Paratyphi A and that the entire clyA gene locus is absent in many other S. enterica serovars, including Typhimurium. The gene...

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Identifiers

PMID: 12228306
DOI: 10.1128/IAI.70.10.5759-5769.2002
PMCID: PMC128311

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Source receipt: pubmed, retrieved 7 Sept 2026.

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