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Article

Disruption of the open conductance in the β-tongue mutants of Cytolysin A.

Scientific reports - 28 Feb 2018

Fahie Monifa A, Liang Lucas, Avelino Alzira R, Pham Bach, Limpikirati Patanachai, Vachet Richard W, Chen Min

Abstract excerpt

Cytolysin A (ClyA) is a water-soluble alpha pore-forming toxin that assembles to form an oligomeric pore on host cell membranes. The ClyA monomer possesses an α-helical bundle with a β-sheet subdomain (the β-tongue) previously believed to be critical for pore assembly and/or insertion. Oligomerization of ClyA pores transforms the β-tongue into a helix-turn-helix that embeds into the lipid bilayer. Here, we show...

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Identifiers

PMID: 29491391
DOI: 10.1038/s41598-018-22009-1
PMCID: PMC5830503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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