Article
The calcium-binding C-terminal domain of Escherichia coli alpha-hemolysin is a major determinant in the surface-active properties of the protein.
The Journal of biological chemistry - 20 Apr 2007
Sánchez-Magraner Lissete, Viguera Ana R, García-Pacios Marcos, Garcillán M Pilar, Arrondo José-Luis R, de la Cruz Fernando, Goñi Félix M, Ostolaza Helena
Abstract excerpt
alpha-Hemolysin (HlyA) from Escherichia coli is a protein toxin (1024 amino acids) that targets eukaryotic cell membranes, causing loss of the permeability barrier. HlyA consists of two main regions, an N-terminal domain rich in amphipathic helices, and a C-terminal Ca(2+)-binding domain containing a Gly- and Asp-rich nonapeptide repeated in tandem 11-17 times. The latter is called the RTX domain and gives its...
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