Article
Identification of individual amino acids required for secretion within the haemolysin (HlyA) C-terminal targeting region.
Molecular microbiology - 1 Jun 1992
Kenny B, Taylor S, Holland I B
Abstract excerpt
The release of haemolysin from Escherichia coli involves direct secretion across both the inner and outer membranes. Secretion of HlyA is dependent upon a specific membrane export complex composed of HlyB, -D and possibly TolC. HlyA is targeted to the medium via the membrane translocation complex, by a novel C-terminal secretion signal. Previous studies involving deletion and fusion analyses have given...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Escherichia coli
- Escherichia coli Proteins
- Hemolysin Proteins
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Protein Conformation