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Article

Power estimation and sample size determination for replication studies of genome-wide association studies.

BMC genomics - 11 Jan 2016

Jiang Wei, Yu Weichuan

Abstract excerpt

BACKGROUND: Replication study is a commonly used verification method to filter out false positives in genome-wide association studies (GWAS). If an association can be confirmed in a replication study, it will have a high confidence to be true positive. To design a replication study, traditional approaches calculate power by treating replication study as another independent primary study. These approaches do not...

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PMID: 26818952
DOI: 10.1186/s12864-015-2296-4
PMCID: PMC4895704

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