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Article

PPARα and PPARγ activators suppress the monocyte-macrophage apoB-48 receptor

1 Jun 2003

Abstract excerpt

Certain triglyceride-rich lipoproteins (TRLs), specifically chylomicrons, dyslipemic VLDLs, and their remnants, are atherogenic and can induce monocyte-macrophage foam cell formation in vitro via the apolipoprotein B-48 receptor (apoB-48R). Human atherosclerotic lesion foam cells express the apoB-48R, as determined immunohistochemically, suggesting it can play a role in the conversion of macrophages into foam...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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Identifiers

PMID: 12700342
DOI: 10.1194/jlr.m300077-jlr200

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