Article
An in vitro Model to Mimic Selection of Replication-Competent HIV-1 Intersubtype Recombination in Dual or Superinfected Patients.
Journal of molecular biology - 7 Jul 2017
Bagaya Bernard S, Tian Meijuan, Nickel Gabrielle C, Vega José F, Li Yuejin, He Ping, Klein Katja, Mann Jamie F S, Jiang Wei, Arts Eric J, Gao Yong
Abstract excerpt
The low frequency of HIV-1 recombinants within entire viral populations in both individual patients and culture-based infection models impedes investigation of the underlying factors contributing to either the occurrence of recombinants or the survival of recombinants once they are formed. So far, most of the related studies have no consideration of recombinants' functionality. Here, we established a functional...
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