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Article

Increased genomic copy number of DEFA1/DEFA3 is associated with susceptibility to severe sepsis in Chinese Han population.

Anesthesiology - 1 Jun 2010

Chen QiXing, Hakimi Matthew, Wu ShuiJing, Jin Yue, Cheng BaoLi, Wang HaiHong, Xie GuoHao, Ganz Tomas, Linzmeier Rose M, Fang XiangMing

Abstract excerpt

BACKGROUND: Human neutrophil peptides 1-3 are endogenous cationic antimicrobial peptides implicated in host defense against microbes. The genes encoding human neutrophil peptides 1-3 (DEFA1/DEFA3) exhibit copy number variations. This study was designed to determine whether DEFA1/DEFA3 copy number variations conferred susceptibility to infection-induced complications such as severe sepsis. METHODS: This...

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Source

Identifiers

PMID: 20502117
DOI: 10.1097/ALN.0b013e3181d968eb

Genes

DEFA1
DEFA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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