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Article

TIM-3 Genetic Variants Are Associated with Altered Clinical Outcome and Susceptibility to Gram-Positive Infections in Patients with Sepsis.

International journal of molecular sciences - 6 Nov 2020

Mewes Caspar, Alexander Tessa, Büttner Benedikt, Hinz José, Alpert Ayelet, Popov Aron-F, Ghadimi Michael, Beißbarth Tim, Tzvetkov Mladen, Grade Marian, Quintel Michael, Bergmann Ingo, Mansur Ashham

Abstract excerpt

Background: Previous studies have reported the fundamental role of immunoregulatory proteins in the clinical phenotype and outcome of sepsis. This study investigated two functional single nucleotide polymorphisms (SNPs) of T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), which has a negative stimulatory function in the T cell immune response. Methods: Patients with sepsis (n = 712) were...

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Identifiers

PMID: 33171904
DOI: 10.3390/ijms21218318
PMCID: PMC7664272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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